Mannitol

Mannitol,1) Reference Standards: CP2000,USP24,BP20002) Quality Identification:ItemCP2000BP 2000USP24AppearanceWhite crystalline powder; odorless, sweet tasteWhite crystalline powder, soluble in water, slightly soluble in ethanol, non-soluble in aetherWhite crystalline powder, soluble in water, slightly soluble in ethanol, non-soluble in aetherMelting point166 170165 170164 169IdentificationPass on testPass on testPass on testAcidity or Basicity≤0.3ml of 0.02mol/L NaOH≤0.3ml of 0.01mol/L HCL or≤0.2ml of 0.01mol/L NaOH≤0.3ml of 0.02mol/L NaOHClarity and color of SolutionClear and colorlessClear and colorlessChloride %≤0.003≤0.005≤0.007Sulphate %≤0.010≤0.010≤0.01Oxalate %≤0.020Residue on ignition %≤0.1≤0.1Loss on drying %≤0.5≤0.5≤0.3Arsenic %≤0.0002≤0.0001Heavy metals %≤0.001≤0. 00005Nickle %≤0.0001Specific optical rotation+23°+25°(in borax solution)+137°+145° (in ammonium molybdate solution)Reducing sugarsNo more than few depositAssay %98.0 102.098.0 101.596.0 101.5Sorbitol %≤2Bacterial endotoxin<100g/l of mannitol,≤4 I.U./g≥100g/l of mannitol,≤2.5 I.U./g